Sepiapterin reductase

In enzymology, a sepiapterin reductase (SPR) (EC 1.1.1.153) is an enzyme that catalyzes the following chemical reaction:

7,8-dihydrobiopterin + NADPH + H⁺ tetrahydrobiopterin + NADP⁺

Thus, the two substrates of this enzyme are 7,8-dihydrobiopterin (DHB, BH₂) and NADP⁺, whereas its three products are tetrahydrobiopterin (THB, BH₄) or sepiapterin, NADPH, and a single hydrogen ion (H⁺).

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 7,8-dihydrobiopterin:NADP+ oxidoreductase. This enzyme participates in folate biosynthesis.

Structural Studies

As of late 2007, five structures have been solved for this class of enzymes, with Protein Data Bank (PDB) accession codes 1NAS, 1OAA, 1SEP, 1Z6Z, and 2BD0.

References

• Katoh S (1971). "Sepiapterin Reductase from Horse Liver: Purification and Properties of the Enzyme.". Arch. Biochem. Biophys. 146 (1): 202–214. doi:10.1016/S0003-9861(71)80057-7. PMID 4401291. 
• Matsubara M, Katoh S, Akino M, Kaufman S (1966). "Sepiapterin Reductase.". Biochim. Biophys. Acta. 122 (2): 202–212. PMID 5969298. 

External links

Gene Ontology (GO) Codes